Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.53 |
| ▸ | IKBKB | O14920 | 3/20 | 0.51 |
| ▸ | CHUK | O15111 | 2/20 | 0.51 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.50 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 4/20 | 0.48 |
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308246 | 0.92 | SYK (0.55) | SYKSMG1JAK2JAK3ACVR1 | |
| SCHEMBL8313329 | 0.91 | SYK (0.53) | SYKIKBKBCHUKIKBKGMTOR | |
| SCHEMBL4392408 | 0.90 | PIK3CA (0.51) | IKBKBCHUKIKBKGMTORSMG1 | |
| SCHEMBL11924733 | 0.90 | MTOR (0.60) | IKBKBCHUKIKBKGMTORSMG1 | |
| SCHEMBL14021190 | 0.90 | MTOR (0.60) | IKBKBCHUKIKBKGMTORSMG1 | |
| SCHEMBL14063782 | 0.89 | JAK2 (0.52) | IKBKBCHUKIKBKGMTORSMG1 | |
| SCHEMBL13590765 | 0.89 | JAK2 (0.51) | IKBKBCHUKIKBKGPIK3CAPIK3CB | |
| SCHEMBL14021219 | 0.88 | PIK3CA (0.58) | IKBKBCHUKIKBKGMTORSMG1 | |
| SCHEMBL14021310 | 0.88 | SYK (0.53) | SYKIKBKBCHUKIKBKGMTOR | |
| SCHEMBL8312167 | 0.88 | JAK2 (0.49) | SYKIKBKBCHUKIKBKGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |