⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL717817 | 0.97 | — | — | |
| Hydrogen Sulfide SCHEMBL11120885 | 0.94 | — | — | |
| SCHEMBL11278954 | 0.89 | — | — | |
| SCHEMBL11273544 | 0.86 | — | — | |
| SCHEMBL11273543 | 0.86 | — | — | |
| SCHEMBL71655 | 0.79 | — | — | |
| SCHEMBL19619130 | 0.79 | — | — | |
| SCHEMBL11276576 | 0.72 | — | — | |
| SCHEMBL11289895 | 0.72 | ALDH1A1 (0.31) | — | |
| SCHEMBL11289901 | 0.72 | ALDH1A1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2631237-A2 | Total synthesis of salinosporamide A and analogs thereof | Nereus Pharmaceuticals, Inc. (US) | 2013-08-28 | — | — | EP | disclosed |
| CN-102718776-A | Total synthesis of salinosporamide A and analogs thereof | NEREUS PHARMACEUTICALS INC | 2012-10-10 | — | — | CN | disclosed |
| EP-2013167-B1 | TOTAL SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS THEREOF | NEREUS PHARMACEUTICALS INC (US) | 2012-09-05 | — | — | EP | disclosed |
| CN-101460457-B | Total synthesis of salinosporamide a and analogs thereof | NERUS PHARMACEUTICALS INC | 2012-07-18 | — | — | CN | disclosed |
| US-8067616-B2 | Total synthesis of salinosporamide A and analogs thereof | NEREUS PHARMACEUTICALS, INC. (US) | 2011-11-29 | — | — | US | disclosed |
| US-20110105762-A1 | TOTAL SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS THEREOF | NEREUS PHARMACEUTICALS, INC. (US) | 2011-05-05 | — | — | US | disclosed |
| US-7842814-B2 | Total synthesis of salinosporamide A and analogs thereof | NEREUS PHARMACEUTICALS, INC. (US) | 2010-11-30 | — | — | US | disclosed |
| EP-1745048-A4 | SIMPLE STEREOCONTROLLED SYNTHESIS OF SALINOSPORAMIDE A | HARVARD COLLEGE (US) | 2009-07-15 | — | — | EP | disclosed |
| CN-101460457-A | Total synthesis of salinosporamide a and analogs thereof | NEREUS PHARMACEUTICALS INC (US) | 2009-06-17 | — | — | CN | disclosed |
| US-7511156-B2 | Analogs of Salinosporamide A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-03-31 | — | — | US | disclosed |
| EP-2013167-A2 | TOTAL SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS THEREOF | Nereus Pharmaceuticals, Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007117591-A9 | TOTAL SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS THEREOF | NEREUS PHARMACEUTICALS INC (US) | 2008-10-02 | — | — | WO | disclosed |
| US-20070249693-A1 | deprotecting, aldol condensations, cleaving double bonds, deesterifying, alcoholization, oxidation with organometallic, lactonization | NEREUS PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | US | disclosed |
| WO-2007117591-A2 | TOTAL SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS THEREOF | NEREUS PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |
| US-20070161693-A1 | Analogs of Salinosporamide A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2007-07-12 | — | — | US | disclosed |
| EP-1745048-A2 | SIMPLE STEREOCONTROLLED SYNTHESIS OF SALINOSPORAMIDE A | The President and Fellows of Harvard College (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005113558-A2 | SIMPLE STEREOCONTROLLED SYNTHESIS OF SALINOSPORAMIDE A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-12-01 | — | — | WO | disclosed |
| WO-2005099687-A2 | ANALOGS OF SALINOSPORAMIDE A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-10-27 | — | — | WO | disclosed |