Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4408045 | 0.99 | HRH3 (0.44) | HRH3PIK3CACHRNB4CHRNA3ADRA2A | |
| SCHEMBL13595234 | 0.90 | HRH3 (0.40) | HRH3CHRNB4CHRNA3ADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL4407120 | 0.89 | HRH3 (0.39) | HRH3CHRNB4CHRNA3ADRA2AADRA2B | |
| SCHEMBL13595219 | 0.83 | TAAR1 (0.42) | TAAR1HTR2CHTR2BKMT2A | |
| Hydrochloric Acid SCHEMBL4410185 | 0.82 | TAAR1 (0.41) | TAAR1HTR2CHTR2BKMT2A | |
| SCHEMBL4409390 | 0.81 | HTR2C (0.37) | TAAR1HTR2CHTR2B | |
| SCHEMBL4415289 | 0.81 | HTR2C (0.45) | ADRA2AADRA2BADRA2CHTR1AHTR2C | |
| Hydrochloric Acid SCHEMBL4409988 | 0.80 | HTR2C (0.44) | ADRA2AADRA2BADRA2CHTR1AHTR2C | |
| Hydrochloric Acid SCHEMBL4418546 | 0.80 | HTR2A (0.36) | TAAR1HTR2CHTR2B | |
| SCHEMBL13595224 | 0.78 | HTR2C (0.47) | HTR2CHTR2BKDM4EMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318412-A1 | Tricyclic heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-24 | — | — | US | disclosed |
| US-20090318412-A1 | Tricyclic heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318412-A1 | Tricyclic heterocyclic compound and use thereof | HTR2C, HTR2A, HTR5A | HRH3 661/4885PIK3CA 2213/4885CHRNB4 429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.