SCHEMBL13596325

SCHEMBL13596325

C[C@H]1CN(C(=N)OC(C)(C)C)CC[C@H]1c1nc(COc2ccc(-n3cnnn3)cc2F)cs1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 20/20 0.59
KCNH2 Q12809 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3487582 0.91 GPR119 (0.66) GPR119
SCHEMBL11885632 0.91 GPR119 (0.66) GPR119
SCHEMBL14874940 0.86 GPR119 (0.57) GPR119
SCHEMBL1118035 0.82 GPR119 (0.78) GPR119
SCHEMBL8024812 0.82 GPR119 (0.54) GPR119KCNH2
SCHEMBL1118394 0.82 GPR119 (0.54) GPR119KCNH2
SCHEMBL8023326 0.82 GPR119 (0.55) GPR119KCNH2
SCHEMBL1118305 0.82 GPR119 (0.65) GPR119KCNH2
SCHEMBL8022934 0.82 GPR119 (0.65) GPR119KCNH2
SCHEMBL3488514 0.82 GPR119 (0.55) GPR119KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7638541-B2 treatment of Type II diabetes and other diseases associated with poor glycemic control METABOLEX INC. (US) 2009-12-29 US disclosed
US-7638541-B2 treatment of Type II diabetes and other diseases associated with poor glycemic control METABOLEX INC. (US) 2009-12-29 US disclosed
US-20090054475-A1 treatment of Type II diabetes and other diseases associated with poor glycemic control METABOLEX, INC. (US) 2009-02-26 US disclosed
US-20090054475-A1 treatment of Type II diabetes and other diseases associated with poor glycemic control METABOLEX, INC. (US) 2009-02-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090054475-A1 treatment of Type II diabetes and other diseases associated with poor glycemic control SLC5A2, IAPP, GPR119 GPR119 3/4885KCNH2 1303/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.