Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12774211 | 0.92 | CHRM1 (0.46) | MAPTALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL12772856 | 0.79 | CHRM1 (0.44) | MAPTALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL446501 | 0.79 | MAPT (0.64) | MAPTALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL917427 | 0.78 | LMNA (0.41) | MAPTALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL917430 | 0.78 | LMNA (0.41) | MAPTALDH1A1GAAKDM4EKMT2A | |
| Iodide SCHEMBL30309834 | 0.77 | MAPT (0.62) | MAPTALDH1A1GAAKDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL27605420 | 0.77 | MAPT (0.62) | MAPTALDH1A1GAAKDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL9704969 | 0.77 | MAPT (0.62) | MAPTALDH1A1GAAKDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL5076170 | 0.77 | LMNA (0.40) | MAPTALDH1A1GAAKDM4EKMT2A | |
| SCHEMBL9391569 | 0.77 | MAPT (0.35) | MAPTALDH1A1GAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |