Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 5/20 | 0.46 |
| ▸ | IMPDH1 | P20839 | 3/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 12/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16418199 | 0.84 | IMPDH2 (0.46) | IMPDH2IMPDH1PSEN1PSEN2APH1B | |
| SCHEMBL1360147 | 0.82 | PSEN1 (0.43) | IMPDH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL16418197 | 0.79 | IMPDH2 (0.46) | IMPDH2IMPDH1PSEN1PSEN2APH1B | |
| SCHEMBL2455975 | 0.77 | PSEN1 (0.64) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1360585 | 0.77 | IMPDH2 (0.44) | IMPDH2IMPDH1PSEN1PSEN2APH1B | |
| SCHEMBL1359516 | 0.75 | IMPDH2 (0.48) | IMPDH2IMPDH1PSEN1PSEN2APH1B | |
| SCHEMBL1360988 | 0.74 | IMPDH2 (0.46) | IMPDH2IMPDH1PSEN1PSEN2APH1B | |
| SCHEMBL1360164 | 0.73 | IMPDH2 (0.41) | IMPDH2IMPDH1PSEN1PSEN2APH1B | |
| SCHEMBL16418212 | 0.73 | IMPDH2 (0.46) | IMPDH2IMPDH1PSEN1PSEN2APH1B | |
| SCHEMBL2228174 | 0.72 | JAK2 (0.49) | IMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150094311-A1 | NOVEL SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS GAMMA SECRETASE MODULATORS | CELLZOME LTD (GB) | 2015-04-02 | — | — | US | disclosed |
| US-8946426-B2 | Substituted bicyclic heterocyclic compounds as gamma secretase modulators | Janssen Pharmaceuticals, Inc. (US) | 2015-02-03 | — | — | US | disclosed |
| EP-2393804-B1 | NOVEL SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS GAMMA SECRETASE MODULATORS | JANSSEN PHARMACEUTICALS INC (US) | 2014-04-16 | — | — | EP | disclosed |
| US-20110281881-A1 | NOVEL SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS GAMMA SECRETASE MODULATORS | CELLZOME LIMITED (GB) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281881-A1 | NOVEL SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS GAMMA SECRETASE MODULATORS | BACE1, BACE2, APH1A | IMPDH2 3553/4885IMPDH1 3421/4885PSEN1 5/4885 |
| US-20150094311-A1 | NOVEL SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS GAMMA SECRETASE MODULATORS | BACE1, BACE2, APH1A | IMPDH2 3553/4885IMPDH1 3421/4885PSEN1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.