Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12496523 | 0.92 | MAPT (0.67) | MAPTGAAPKML3MBTL1ALDH1A1 | |
| SCHEMBL13601724 | 0.85 | MAPT (0.44) | MAPTGAAPKML3MBTL1ALDH1A1 | |
| SCHEMBL14477874 | 0.84 | MAPT (0.59) | MAPTGAAPKML3MBTL1ALDH1A1 | |
| SCHEMBL12881458 | 0.84 | MAPT (0.64) | MAPTGAAPKML3MBTL1ALDH1A1 | |
| SCHEMBL12881469 | 0.84 | MAPT (0.59) | MAPTGAAPKML3MBTL1ALDH1A1 | |
| SCHEMBL12884062 | 0.84 | MAPT (0.55) | MAPTGAAPKML3MBTL1ALDH1A1 | |
| SCHEMBL6331933 | 0.83 | MAPT (0.62) | MAPTGAAPKML3MBTL1ALDH1A1 | |
| SCHEMBL13601726 | 0.82 | SMN1; SMN2 (0.45) | MAPTGAAALDH1A1KDM4EHTR1A | |
| SCHEMBL1819086 | 0.82 | MAPT (0.61) | MAPTGAAPKML3MBTL1ALDH1A1 | |
| SCHEMBL9153460 | 0.81 | ALDH1A1 (0.62) | MAPTGAAALDH1A1KDM4EHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |