Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16243453 | 0.77 | MAPT (0.48) | MAPTLMNAKDM4EHTTNPSR1 | |
| SCHEMBL397235 | 0.77 | MAPT (0.48) | MAPTLMNAKDM4EHTTNPSR1 | |
| SCHEMBL255765 | 0.75 | MAPT (0.47) | MAPTLMNAKDM4EHTTNPSR1 | |
| SCHEMBL14994629 | 0.75 | MAPT (0.47) | MAPTLMNAKDM4EHTTNPSR1 | |
| SCHEMBL16794657 | 0.75 | MAPT (0.47) | MAPTLMNAKDM4EHTTNPSR1 | |
| SCHEMBL4055908 | 0.72 | MAPT (0.44) | MAPTLMNAKDM4EHTTNPSR1 | |
| SCHEMBL20945316 | 0.72 | MAPT (0.44) | MAPTLMNAKDM4EHTTNPSR1 | |
| SCHEMBL19513633 | 0.72 | BRD4 (0.47) | — | |
| SCHEMBL15574180 | 0.71 | CYP3A4 (0.52) | MAPTLMNAKDM4EHTTNPSR1 | |
| SCHEMBL16489427 | 0.71 | TSHR (0.50) | MAPTLMNAKDM4EHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629338-B2 | Substituted monocyclic CGRP receptor antagonists | MERCK & CO., INC. (US) | 2009-12-08 | — | — | US | disclosed |