Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 3/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13600711 | 1.00 | HTR4 (0.43) | HTR4HTR3ACHRM2CHRM4CHRM1 | |
| SCHEMBL13607404 | 0.96 | HTR4 (0.42) | HTR4HTR3ACHRM2CHRM4CHRM1 | |
| SCHEMBL13600697 | 0.96 | HTR4 (0.42) | HTR4HTR3ACHRM2CHRM4CHRM1 | |
| SCHEMBL13607553 | 0.90 | HTR4 (0.43) | HTR4HTR3ACHRM2CHRM4CHRM1 | |
| SCHEMBL13600644 | 0.90 | HTR4 (0.43) | HTR4HTR3ACHRM2CHRM4CHRM1 | |
| SCHEMBL13315513 | 0.87 | HTR4 (0.41) | HTR4HTR3ACHRM2CHRM4CHRM1 | |
| SCHEMBL13607651 | 0.87 | HTR4 (0.41) | HTR4HTR3ACHRM2CHRM4CHRM1 | |
| SCHEMBL13349283 | 0.86 | HTR4 (0.40) | HTR4HTR3ACHRM2CHRM4CHRM1 | |
| SCHEMBL13600653 | 0.86 | HTR4 (0.42) | HTR4HTR3ACHRM2CHRM4CHRM1 | |
| SCHEMBL13607704 | 0.86 | HTR4 (0.42) | HTR4HTR3ACHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635706-B2 | 1-butyl-3-hydroxy4-piperidinyl)methyl 8-amino-7-chloro-2,3-dihydro-1,4-benzodioxin-5-carboxylate and chemical intermediates; treating hypermotility, irritable bowel syndrome (IBS) constipation or diarrhea predominant IBS, pain and non-pain predominant IBS and bowel hypersensitivity | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-22 | — | — | US | disclosed |