Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13607779 | 0.86 | GAA (0.50) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL13607801 | 0.84 | GAA (0.42) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL13607799 | 0.82 | CDK5 (0.48) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL13607793 | 0.82 | RNASEH1 (0.43) | LMNAEGFRMAPK1KMT2AADORA2A | |
| SCHEMBL13607784 | 0.81 | MAPT (0.40) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL13607786 | 0.81 | HPGD (0.44) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL13607789 | 0.81 | PDE5A (0.46) | LMNARAB9AMAPTEGFRTAAR1 | |
| SCHEMBL13607772 | 0.81 | GRIN1 (0.47) | LMNASMN1; SMN2POLBGAAHTT | |
| SCHEMBL13607781 | 0.80 | SMN1; SMN2 (0.48) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL4058306 | 0.79 | SMN1; SMN2 (0.52) | LMNASMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |