RNASEH1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL37942	0.45	3/20
SCHEMBL1553610	0.44	3/20
SCHEMBL38005	0.42	3/20
SCHEMBL38178	0.42	3/20
SCHEMBL891835	0.39	3/20
SCHEMBL6357709	0.60	2/20
SCHEMBL405399	0.60	2/20
SCHEMBL405327	0.56	2/20
SCHEMBL405533	0.56	2/20
SCHEMBL405606	0.56	2/20
SCHEMBL5677631	0.55	2/20
SCHEMBL259477	0.55	2/20
SCHEMBL400090	0.54	2/20
SCHEMBL37513	0.53	2/20
SCHEMBL3494163	0.53	2/20
SCHEMBL6594881	0.52	2/20
SCHEMBL456753	0.51	2/20
SCHEMBL6619853	0.51	2/20
SCHEMBL6620304	0.51	2/20
SCHEMBL6593358	0.49	2/20

Clinical trials — most relevant to RNASEH1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Long Term Extension Study in Patients With Primary Hyperoxaluria	PHASE3	ACTIVE_NOT_RECRUITING
Reverse Transcriptase Inhibitors in AGS	PHASE2	COMPLETED
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma	PHASE1/PHASE2	COMPLETED
Safety and Efficacy Study of ISIS 301012 (Mipomersen) Administration in High Risk Statin Intolerant Subjects	PHASE2	COMPLETED
Phase 1b Safety Study of IMSB301 in Type 1 Interferonopathies	PHASE1	RECRUITING
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing	nan	RECRUITING
Diagnosis of Inflammatory Bowel Disease	nan	NOT_YET_RECRUITING
Expression Pattern of HNRNPH1 and HNRNPK Genes in MPNs	nan	UNKNOWN
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis	nan	COMPLETED
International PPB/DICER1 Registry	nan	RECRUITING
NFC Changes in SLE Patients and Its Correlation With Anti-U1RNPAntibodies and Disease Activity	nan	UNKNOWN
X-chromosome Inactivation, Epigenetics and the Transcriptome	nan	COMPLETED
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
The Value of circRNAs (hsa_circ_0004001) in Early Diagnosis of HCC	nan	UNKNOWN
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve	nan	UNKNOWN
Liquid Biopsy for Early Detection of Colorectal Cancer Using Circular RNA	nan	RECRUITING
Genetic Investigation of Cancer Predisposition	nan	NOT_YET_RECRUITING
PCD New Gene Discovery	nan	COMPLETED
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study	nan	RECRUITING
Evaluation of a ddPCR Technology for the SARS-CoV-2 Detection in Symptomatic Patients With Suspicion of COVID-19	nan	COMPLETED
Impact of Weight Loss on the Human Sperm Epitranscriptome	nan	ACTIVE_NOT_RECRUITING
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Study of Specimens From Young Patients With Neuroblastoma	nan	COMPLETED
Biomarkers in Patients With Diffuse Large B-Cell Lymphoma Treated With Combination Chemotherapy With or Without Rituximab	nan	COMPLETED
Clinical Genetics Branch Eligibility Screening Survey	nan	NOT_YET_RECRUITING
Longitudinal Study of Neurogenetic Disorders	nan	RECRUITING
A Prospective, Multicenter, Collaborative Study to Determine the Prevalence of Nontuberculous Mycobacteria (NTM) in Pediatric Patients With Cystic Fibrosis in Florida	nan	COMPLETED
Role of Genetic Factors in the Development of Lung Disease	nan	RECRUITING
Diagnosis and Phenotype Characterisation Using Genomics in Patients With Inherited Bone Marrow Failure (IBMDx Study)	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a RNASEH1 binder may also engage these)

Protein	Name	Similarity
O70338	—	1.000	O70338 →
Q5BK46	—	1.000	Q5BK46 →
Q754C9	—	0.983	Q754C9 →
O70157	—	0.981	O70157 →
Q9H0M0	—	0.978	Q9H0M0 →
P39867	—	0.978	P39867 →
Q9UST8	—	0.978	Q9UST8 →
Q75LI2	—	0.978	Q75LI2 →
P27967	—	0.978	P27967 →
Q8LPU5	—	0.977	Q8LPU5 →
Q5R6G3	—	0.977	Q5R6G3 →
O60231	—	0.977	O60231 →
Q9AWM8	—	0.977	Q9AWM8 →
P25799	—	0.977	P25799 →
Q9S7G6	—	0.977	Q9S7G6 →
Q8LQJ8	—	0.976	Q8LQJ8 →
B4GEU1	—	0.976	B4GEU1 →
Q2VF18	—	0.976	Q2VF18 →
KDM5D	Lysine-specific demethylase 5D	0.976	landscape →
A4RHU9	—	0.976	A4RHU9 →
P27783	—	0.976	P27783 →
A4RKC3	—	0.976	A4RKC3 →
Q9LVM5	—	0.976	Q9LVM5 →
Q9ARI6	—	0.976	Q9ARI6 →
Q8LI34	—	0.976	Q8LI34 →
B2ZFP3	—	0.976	B2ZFP3 →
Q9SS38	—	0.976	Q9SS38 →
Q5JKF2	—	0.976	Q5JKF2 →
Q62940	—	0.976	Q62940 →
Q9ZSV1	—	0.976	Q9ZSV1 →