Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 3/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13607783 | 0.92 | POLB (0.57) | POLBKDM4EALDH1A1GAAHPGD | |
| SCHEMBL13607772 | 0.84 | GRIN1 (0.47) | POLBGAAPDGFRBSMN1; SMN2GRIN1 | |
| SCHEMBL13607808 | 0.83 | ALDH1A1 (0.42) | POLBALDH1A1GAACCNB2CDK1 | |
| SCHEMBL13608262 | 0.83 | POLB (0.50) | POLBKDM4EALDH1A1HPGDPDGFRB | |
| SCHEMBL13607781 | 0.81 | SMN1; SMN2 (0.48) | POLBALDH1A1SMN1; SMN2GRIN1GRIN2B | |
| SCHEMBL13607812 | 0.81 | POLB (0.44) | POLBKDM4EGAASMN1; SMN2 | |
| SCHEMBL4058869 | 0.81 | RXFP1 (0.54) | POLBKDM4EALDH1A1GAAHPGD | |
| SCHEMBL13607799 | 0.81 | CDK5 (0.48) | POLBALDH1A1GAACCNB2CDK1 | |
| SCHEMBL13607782 | 0.80 | HSP90AA1 (0.47) | POLBPDGFRBSMN1; SMN2DHFRHTT | |
| SCHEMBL13608281 | 0.79 | POLB (0.43) | POLBKDM4EALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |