Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 2/20 | 0.33 |
| ▸ | FNTB | P49356 | 2/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13609196 | 0.87 | FYN (0.36) | CAMKK2FYNBRD4 | |
| SCHEMBL13745780 | 0.86 | CAMKK2 (0.41) | CAMKK2FYNFEN1BRD4 | |
| SCHEMBL13609199 | 0.85 | CYP11B1 (0.39) | KDM4EALDH1A1L3MBTL1ALOX5APFEN1 | |
| SCHEMBL13745928 | 0.85 | CAMKK2 (0.41) | CAMKK2FYNFEN1BRD4 | |
| SCHEMBL13609210 | 0.84 | CAMKK2 (0.40) | CAMKK2FYNSCN9AFEN1BRD4 | |
| SCHEMBL13746316 | 0.83 | CAMKK2 (0.37) | CAMKK2FYNALOX5APFEN1BRD4 | |
| SCHEMBL13746255 | 0.83 | FYN (0.38) | CAMKK2FYNSCN9ABRD4 | |
| SCHEMBL13746271 | 0.83 | CAMKK2 (0.37) | CAMKK2FYNFEN1BRD4 | |
| SCHEMBL13746535 | 0.83 | CAMKK2 (0.41) | CAMKK2FYNALOX5APFEN1BRD4 | |
| SCHEMBL13746565 | 0.83 | CAMKK2 (0.39) | CAMKK2FYNBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612086-B2 | Jun N-terminal kinase inhibitors; 1H-pyrrolo[2,3-b]pyridines 3-substituted with a C 5-7 carbocycle and 5-substituted by a 5-member heterocycle; 3-(p-(dimethylamino)phenyl)-5-(2-thiazolyl-1H-pyrrolo[2,3-b]pyridine; neurodegenerative disorders related to apoptosis and/or inflammation | EISAI R & D MANAGEMENT CO. LTD. (JP) | 2009-11-03 | — | — | US | disclosed |