⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3744556 | 0.67 | IDO1 (0.50) | — | |
| SCHEMBL1548449 | 0.62 | — | — | |
| SCHEMBL1822949 | 0.62 | — | — | |
| SCHEMBL14416088 | 0.62 | — | — | |
| SCHEMBL16433080 | 0.60 | — | — | |
| SCHEMBL595649 | 0.57 | — | — | |
| SCHEMBL7995627 | 0.57 | — | — | |
| SCHEMBL1999085 | 0.57 | — | — | |
| SCHEMBL2238449 | 0.57 | — | — | |
| SCHEMBL1083825 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037931-B2 | Corticotropin releasing factor moderator; analgesics; drug abruse, drug dependency; schizophrenia | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-02 | — | — | US | claimed |
| US-20050020565-A1 | Pyrazole compound; gastrointestinal disorders; central nervous system disorders | JONES TODD K (US) | 2005-01-27 | — | — | US | claimed |
| EP-1077957-B1 | OXYIMINOALKANOIC ACID DERIVATIVES WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-08-04 | — | — | EP | claimed |
| US-20040067983-A1 | CCK-1 receptor modulators | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-04-08 | — | — | US | claimed |
| US-8067453-B2 | Oxazole compound to treat or prevent diabetic neuropathy; 4-(4-chlorophenyl)-5-(3-(2-methoxyphenoxy)propyl-2-methyl-1-imidazolyl)oxazole | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-29 | — | — | US | disclosed |
| US-20100029724-A1 | SCREENING METHOD | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2010-02-04 | — | — | US | disclosed |
| EP-2039779-A1 | SCREENING METHOD | Takeda Pharmaceutical Company Limited (JP) | 2009-03-25 | — | — | EP | disclosed |
| US-7498352-B2 | TGF-β superfamily production/secretion promoter | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-03-03 | — | — | US | disclosed |
| US-7465808-B2 | CCK-1 receptor modulators | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-12-16 | — | — | US | disclosed |
| US-7462635-B2 | Thiazole and oxazole VDAC regulator | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-09 | — | — | US | disclosed |
| US-20080287438-A1 | Agent for preventing or treating neuropathy | MOMOSE YU | 2008-11-20 | — | — | US | disclosed |
| US-20080269219-A1 | Neurotrophin production/secretion promoting agent | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-10-30 | — | — | US | disclosed |
| US-4959299-A | DEVELOPMENT INHIBITOR-RELEASING AND BLEACH ACCELERATING AGENT-RELEASING COUPLERS | FUJI PHOTO FILM CO., LTD. (JP) | 1990-09-25 | — | — | US | disclosed |
| US-4883879-A | CHEMICAL INTERMEDIATES | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1989-11-28 | — | — | US | disclosed |
| US-4822786-A | Cephalosporin compounds, and antibacterial agents | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0305939-A1 | Process of producing sulfonylurea derivatives | Takeda Chemical Industries, Ltd. (JP) | 1989-03-08 | — | — | EP | disclosed |
| EP-0251299-A2 | Cephalosporin compounds, processes for their preparation and antibacterial agents | Kaken Pharmaceutical Co., Ltd. (JP) | 1988-01-07 | — | — | EP | disclosed |
| EP-0238070-A2 | Sulfonylurea compounds, their production and herbicidal use | Takeda Chemical Industries, Ltd. (JP) | 1987-09-23 | — | — | EP | disclosed |
| US-4400517-A | PESTICIDES; APHIDICIDES; PARASITICIDES | MONTEDISON S.P.A. (IT) | 1983-08-23 | — | — | US | disclosed |
| US-4220789-A | CYCLIZATION OF A SEMICARBAZONE | MONTEDISON S.P.A. (IT) | 1980-09-02 | — | — | US | disclosed |