Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 10/20 | 0.71 |
| ▸ | MAOB | P27338 | 10/20 | 0.71 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 2/20 | 0.37 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1830929 | 0.83 | MAOA (0.78) | MAOAMAOBPSEN1PSEN2APH1B | |
| SCHEMBL729786 | 0.83 | MAOA (1.00) | MAOAMAOBCYP2E1CYP2A6NPC1 | |
| SCHEMBL727784 | 0.81 | MAOA (1.00) | MAOAMAOBPSEN1PSEN2APH1B | |
| SCHEMBL13674803 | 0.81 | MAOA (0.74) | MAOAMAOBPSEN1PSEN2APH1B | |
| SCHEMBL1903038 | 0.80 | MAOA (1.00) | MAOAMAOBPOLB | |
| SCHEMBL1840202 | 0.80 | MAOA (0.71) | MAOAMAOB | |
| SCHEMBL1899267 | 0.79 | MAOA (0.71) | MAOAMAOBCYP2E1CYP2A6 | |
| SCHEMBL728231 | 0.79 | MAOA (0.78) | MAOAMAOBPSEN1PSEN2APH1B | |
| SCHEMBL12669488 | 0.73 | MAOA (0.55) | MAOAMAOBCYP2E1CYP2A6PSEN1 | |
| SCHEMBL1828774 | 0.73 | MAOA (1.00) | MAOAMAOBPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315588-B1 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW MAO INHIBITORS AND IMIDAZOLINE RECEPTOR LIGANDS | ROTTAPHARM SPA (IT) | 2012-12-19 | — | — | EP | disclosed |
| WO-2009152868-A1 | 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW MAO INHIBITORS AND IMIDAZOLINE RECEPTOR LIGANDS | ROTTAPHARM S.P.A. (IT) | 2009-12-23 | — | — | WO | disclosed |