SCHEMBL13610874

SCHEMBL13610874

COc1ccc(C)cc1-n1c(C)cc(OCc2ccc(F)cc2F)cc1=O

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 18/20 0.54
PTGER1 P34995 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4383567 0.86 MAPK14 (0.60) MAPK14PTGER1
SCHEMBL13610872 0.82 MAPK14 (0.75) MAPK14
SCHEMBL4376955 0.80 MAPK14 (0.56) MAPK14
SCHEMBL4381266 0.78 MAPK14 (0.65) MAPK14
SCHEMBL6500401 0.78 MAPK14 (0.45) MAPK14PTGER1
SCHEMBL13610118 0.78 GSK3B (0.47) MAPK14PTGER1
SCHEMBL6506871 0.78 MAPK14 (0.53) MAPK14PTGER1
SCHEMBL4376549 0.78 MAPK14 (0.52) MAPK14PTGER1
SCHEMBL4377892 0.77 MAPK14 (0.47) MAPK14PTGER1
SCHEMBL4378989 0.77 MAPK14 (0.46) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7629363-B2 antiinflammatory agent for treating asthma and chronic pulmonary inflammatory disease PFIZER INC (US) 2009-12-08 US disclosed