Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 17/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4286476 | 0.94 | NR3C1 (0.52) | NR3C1PGRSMOCYP11B1CYP11B2 | |
| SCHEMBL4283291 | 0.88 | NR3C1 (0.60) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL4279047 | 0.87 | NR3C1 (0.58) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL4285041 | 0.85 | NR3C1 (0.59) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL4288032 | 0.85 | NR3C1 (0.56) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL4285162 | 0.85 | NR3C1 (0.62) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL4286710 | 0.84 | NR3C1 (0.51) | NR3C1PGRSMO | |
| SCHEMBL4273883 | 0.84 | NR3C1 (0.59) | NR3C1PGRSMO | |
| SCHEMBL4286455 | 0.84 | NR3C1 (0.61) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL4283417 | 0.83 | NR3C1 (0.50) | NR3C1PGRSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622594-B2 | Glucocortioid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |