SCHEMBL13611176

SCHEMBL13611176

O=c1c(Cl)c(OCc2ccc(F)cc2F)ccn1-c1c(F)cc(CN(Cl)CC2CC2)cc1F

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 19/20 0.46
PREP P48147 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13610862 0.85 MAPK14 (0.55) MAPK14
SCHEMBL4379119 0.84 MAPK14 (0.44) MAPK14PREP
SCHEMBL13602920 0.83 MAPK14 (0.45) MAPK14PREP
Hydrochloric Acid SCHEMBL4377579 0.82 MAPK14 (0.44) MAPK14PREP
SCHEMBL4384896 0.81 MAPK14 (0.52) MAPK14
Hydrochloric Acid SCHEMBL4376642 0.80 MAPK14 (0.51) MAPK14
SCHEMBL13610744 0.80 MAPK14 (0.50) MAPK14
SCHEMBL13602931 0.79 MAPK14 (0.52) MAPK14
Hydrochloric Acid SCHEMBL4379526 0.78 MAPK14 (0.51) MAPK14
SCHEMBL4377050 0.77 MAPK14 (0.48) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7629363-B2 antiinflammatory agent for treating asthma and chronic pulmonary inflammatory disease PFIZER INC (US) 2009-12-08 US disclosed