Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 8/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7792914 | 0.82 | ALDH1A1 (0.57) | CYP1A2CYP2C19NPSR1NPC1RAB9A | |
| SCHEMBL12683029 | 0.77 | CYP1A2 (0.46) | CYP1A2CYP2D6CYP2C19NPSR1NPC1 | |
| SCHEMBL12021767 | 0.76 | ALDH1A1 (0.55) | RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL17556058 | 0.76 | MEN1 (0.69) | NPSR1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL13578883 | 0.75 | KMT2A (0.55) | RAB9AALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL15568782 | 0.73 | KDM4E (0.43) | CYP1A2CYP2D6CYP2C19NPSR1NPC1 | |
| SCHEMBL387677 | 0.73 | SMN1; SMN2 (0.42) | CYP1A2CYP2D6CYP2C19NPSR1NPC1 | |
| SCHEMBL20503075 | 0.72 | KDM4E (0.42) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL22900489 | 0.71 | KMT2A (0.46) | CYP1A2CYP2D6CYP2C19NPSR1NPC1 | |
| SCHEMBL4338135 | 0.70 | NR1H2 (0.49) | CYP1A2CYP2D6CYP2C19NPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1967516-B1 | 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as MEK inhibitors for the treatment of hyperproliferative diseases | ARRAY BIOPHARMA INC (US) | 2009-11-04 | — | — | EP | disclosed |