Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 20/20 | 0.59 |
| ▸ | KLKB1 | P03952 | 9/20 | 0.59 |
| ▸ | PLAT | P00750 | 5/20 | 0.59 |
| ▸ | KLK1 | P06870 | 1/20 | 0.59 |
| ▸ | F10 | P00742 | 5/20 | 0.56 |
| ▸ | F9 | P00740 | 2/20 | 0.53 |
| ▸ | PLG | P00747 | 4/20 | 0.51 |
| ▸ | PROC | P04070 | 2/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.51 |
| ▸ | F7 | P08709 | 1/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12012893 | 0.95 | F11 (0.60) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1196864 | 0.92 | F11 (0.71) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1196866 | 0.92 | F11 (0.71) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1197574 | 0.86 | F11 (0.74) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1920231 | 0.86 | F11 (0.74) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1196342 | 0.84 | F11 (0.74) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1196340 | 0.84 | F11 (0.74) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1196976 | 0.82 | F11 (0.75) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1196973 | 0.82 | F11 (0.75) | F11KLKB1PLATKLK1F10 | |
| SCHEMBL1196975 | 0.82 | F11 (0.75) | F11KLKB1PLATKLK1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7626039-B2 | Arylpropionamide, arylacrylamide, ayrlpropynamide, or arylmethylurea analogs as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-01 | — | — | US | disclosed |