Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 14/20 | 0.60 |
| ▸ | GRIA2 | P42262 | 12/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377898 | 0.91 | GRIA4 (0.59) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL8287328 | 0.90 | GRIA4 (0.57) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL8287321 | 0.90 | GRIA4 (0.59) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL8288356 | 0.89 | GRIA4 (0.60) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL8287317 | 0.89 | GRIA4 (0.72) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL8287331 | 0.88 | GRIA4 (0.61) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL8289342 | 0.87 | GRIA4 (0.78) | GRIA4GRIA2 | |
| SCHEMBL8288393 | 0.87 | GRIA4 (0.60) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL4373116 | 0.87 | GRIA4 (0.57) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL8288359 | 0.85 | GRIA4 (0.58) | GRIA4GRIA2ALDH1A1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625932-B2 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | ELI LILLY AND COMPANY (US) | 2009-12-01 | — | — | US | disclosed |
| US-20070066573-A1 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066573-A1 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | GRIN1, GRIN3A, GRIK5 | GRIA4 16/4885GRIA2 17/4885ALDH1A1 2211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.