Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 14/20 | 0.61 |
| ▸ | GRIA2 | P42262 | 12/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288393 | 0.88 | GRIA4 (0.60) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL8288356 | 0.88 | GRIA4 (0.60) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL8289342 | 0.88 | GRIA4 (0.78) | GRIA4GRIA2 | |
| SCHEMBL13611770 | 0.88 | GRIA4 (0.60) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL8288359 | 0.86 | GRIA4 (0.58) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL13863259 | 0.80 | GRIA4 (0.48) | GRIA4GRIA2ALDH1A1KDM4E | |
| SCHEMBL4375364 | 0.80 | GRIA4 (0.61) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL4373283 | 0.80 | GRIA4 (0.60) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL4372491 | 0.80 | GRIA4 (0.61) | GRIA4GRIA2ALDH1A1KDM4EHTT | |
| SCHEMBL4375140 | 0.80 | GRIA4 (0.55) | GRIA4GRIA2ALDH1A1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-B1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |