Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 10/20 | 0.40 |
| ▸ | KDR | P35968 | 6/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9885160 | 0.87 | GSK3B (0.42) | KIF11KDRPDGFRBIDO1TDO2 | |
| SCHEMBL3206124 | 0.87 | FEN1 (0.44) | KDRPDGFRBCHEK2JAK3 | |
| SCHEMBL3212694 | 0.86 | MAP2 (0.42) | KIF11AAK1CHEK2 | |
| SCHEMBL3215596 | 0.86 | TNKS2 (0.45) | KIF11PDGFRBIDO1TDO2CHEK2 | |
| SCHEMBL3217348 | 0.86 | KIF11 (0.48) | KIF11KDRPDGFRBPLK4CHEK2 | |
| SCHEMBL3206899 | 0.85 | GSK3B (0.43) | — | |
| SCHEMBL3217971 | 0.84 | PDGFRB (0.38) | KIF11KDRPDGFRBAAK1 | |
| SCHEMBL3195669 | 0.84 | CHUK (0.38) | KIF11KDRPDGFRBIDO1TDO2 | |
| Hydrochloric Acid SCHEMBL3833817 | 0.82 | PDGFRB (0.38) | KIF11KDRPDGFRBAAK1 | |
| SCHEMBL3220420 | 0.82 | JAK2 (0.47) | DYRK1BCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119703-B1 | NOVEL INDOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON I B KINASE | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-12-12 | — | — | EP | disclosed |
| EP-2119703-A1 | NOVEL INDOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON I B KINASE | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-18 | — | — | EP | disclosed |