Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835325 | 0.88 | DYRK1A (0.35) | MKNK1MKNK2ABL1AAK1GSK3B | |
| SCHEMBL3194737 | 0.87 | CCNC (0.46) | MKNK1MKNK2MAPTGSK3BMAPK1 | |
| SCHEMBL3206899 | 0.86 | GSK3B (0.43) | PDPK1CDC7ABL1GSK3B | |
| SCHEMBL3205809 | 0.86 | GSK3B (0.47) | MKNK1MKNK2ABL1GSK3BMAPK1 | |
| SCHEMBL3836025 | 0.84 | MYC (0.53) | AAK1GSK3BMAPK1NR3C2DYRK1A | |
| SCHEMBL9885160 | 0.84 | GSK3B (0.42) | ABL1AAK1GSK3B | |
| SCHEMBL3206124 | 0.81 | FEN1 (0.44) | GSK3B | |
| SCHEMBL3214652 | 0.81 | LRRK2 (0.41) | ABL1BTKAAK1MAPK1DYRK1A | |
| SCHEMBL3209490 | 0.81 | AAK1 (0.46) | MKNK2PDPK1BTKAAK1 | |
| SCHEMBL3217348 | 0.80 | KIF11 (0.48) | CDC7ABL1MAPTGSK3BROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119703-A1 | NOVEL INDOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON I B KINASE | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-18 | — | — | EP | disclosed |