Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | MAP2 | P11137 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | LRP6 | O75581 | 1/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27785243 | 0.83 | AR (0.39) | ARMAP2LRRK2KDM4EMAP2K7 | |
| SCHEMBL3834396 | 0.81 | AR (0.43) | ARMAP2LRRK2KDM4EMAP2K7 | |
| SCHEMBL3201691 | 0.77 | AR (0.40) | ARMAP2LRRK2KDM4EMAP2K7 | |
| SCHEMBL13613294 | 0.76 | GRIK1 (0.34) | MAPTBTKMITFABL1 | |
| SCHEMBL14236517 | 0.75 | AR (0.42) | ARBTKABL1 | |
| SCHEMBL27763402 | 0.74 | LRRK2 (0.45) | MAP2LRRK2MAP2K7PARP1ABL1 | |
| SCHEMBL13613557 | 0.68 | PARP1 (0.31) | ARMAP2KDM4EMAPTALDH1A1 | |
| SCHEMBL3209276 | 0.68 | GSK3B (0.45) | MAP2LRRK2MAP2K7PARP1ABL1 | |
| SCHEMBL22372423 | 0.67 | AR (0.49) | ARMAP2KDM4EMAPTALDH1A1 | |
| SCHEMBL3835703 | 0.66 | LRRK2 (0.47) | MAP2LRRK2MAP2K7PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119703-A1 | NOVEL INDOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON I B KINASE | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-18 | — | — | EP | disclosed |