Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAP2 | P11137 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3834396 | 0.86 | AR (0.43) | PARP1KDM4EALDH1A1MAP2MAPT | |
| SCHEMBL3217527 | 0.78 | FEN1 (0.44) | PARP1KDM4EALDH1A1MAP2MEN1 | |
| SCHEMBL3210534 | 0.78 | PDPK1 (0.42) | PARP1 | |
| SCHEMBL3197903 | 0.78 | CA1 (0.49) | PARP1KDM4EALDH1A1MAP2MEN1 | |
| SCHEMBL3828991 | 0.78 | MITF (0.51) | KDM4EALDH1A1MITFMAPTGAA | |
| SCHEMBL3833775 | 0.77 | KMT2A (0.37) | ALDH1A1KMT2A | |
| SCHEMBL349187 | 0.76 | PARP1 (0.49) | PARP1KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL14236512 | 0.75 | KDR (0.42) | KDM4EALDH1A1MAPTGAA | |
| SCHEMBL15146065 | 0.74 | PIN1 (0.41) | PARP1MAP2AR | |
| SCHEMBL3197218 | 0.74 | KIF11 (0.55) | ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119703-A1 | NOVEL INDOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON I B KINASE | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-18 | — | — | EP | disclosed |