Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | HPGD | P15428 | 5/20 | 0.67 |
| ▸ | EGFR | P00533 | 3/20 | 0.61 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.55 |
| ▸ | PRKACA | P17612 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | ATR | Q13535 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3988108 | 0.86 | RPS6KA5 (0.67) | KDM4EALDH1A1HPGDEGFRRPS6KA5 | |
| SCHEMBL3981904 | 0.82 | RPS6KA5 (0.67) | KDM4EALDH1A1HPGDEGFRRPS6KA5 | |
| SCHEMBL3945031 | 0.82 | RPS6KA5 (0.61) | KDM4EALDH1A1HPGDEGFRRPS6KA5 | |
| SCHEMBL21777019 | 0.81 | KDM4E (1.00) | KDM4EALDH1A1HPGDRPS6KA5RPS6KB1 | |
| SCHEMBL13606525 | 0.80 | KDM4E (0.55) | KDM4EALDH1A1HPGDEGFRRPS6KA5 | |
| SCHEMBL3987719 | 0.78 | RPS6KA5 (0.65) | KDM4EALDH1A1HPGDEGFRRPS6KA5 | |
| SCHEMBL3949889 | 0.77 | EGFR (1.00) | EGFR | |
| SCHEMBL3948649 | 0.77 | EGFR (0.81) | EGFR | |
| SCHEMBL3983558 | 0.76 | RPS6KA5 (0.66) | EGFRRPS6KA5RPS6KB1ROCK1ATR | |
| SCHEMBL13606520 | 0.76 | RPS6KA5 (0.56) | EGFRRPS6KA5RPS6KB1ROCK1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318472-A1 | AMINOPYRAZINE DERIVATIVES AND COMPOSITIONS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318472-A1 | AMINOPYRAZINE DERIVATIVES AND COMPOSITIONS | STK25, ABL1, STK35 | KDM4E 1345/4885ALDH1A1 3409/4885HPGD 1740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.