Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 1.00 |
| ▸ | HPGD | P15428 | 6/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | HTT | P42858 | 3/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | GFER | P55789 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.65 |
| ▸ | TP53 | P04637 | 4/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310612 | 0.88 | KDM4E (0.78) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL19275978 | 0.87 | KDM4E (0.77) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL5009162 | 0.87 | KDM4E (0.77) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL29991849 | 0.84 | KDM4E (0.73) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL21769699 | 0.84 | KDM4E (0.73) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL18969121 | 0.84 | KDM4E (0.73) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL11440211 | 0.84 | KDM4E (0.73) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL11313561 | 0.84 | KDM4E (0.73) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL16692218 | 0.84 | KDM4E (0.73) | KDM4EALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL31267426 | 0.84 | KDM4E (0.72) | KDM4EALDH1A1HPGDRAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210395242-A1 | HETEROCYCLIC COMPOUNDS AS AHR MODULATORS | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2021-12-23 | — | — | US | disclosed |
| US-20210395242-A1 | HETEROCYCLIC COMPOUNDS AS AHR MODULATORS | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2021-12-23 | — | — | US | disclosed |
| EP-3843853-A1 | HETEROCYCLIC COMPOUNDS AS AHR MODULATORS | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020043880-A1 | HETEROCYCLIC COMPOUNDS AS AHR MODULATORS | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2020-03-05 | — | — | WO | disclosed |
| WO-2020043880-A1 | HETEROCYCLIC COMPOUNDS AS AHR MODULATORS | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210395242-A1 | HETEROCYCLIC COMPOUNDS AS AHR MODULATORS | AHR, ARNT, AIPL1 | KDM4E 1044/4885ALDH1A1 253/4885HPGD 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.