Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5129575 | 0.74 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL2734347 | 0.72 | ALDH1A1 (0.32) | ALDH1A1MAPTNPC1 | |
| SCHEMBL7047176 | 0.64 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL27514230 | 0.62 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL16372678 | 0.62 | MEN1 (0.42) | ALDH1A1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL14037418 | 0.62 | MAPT (0.40) | ALDH1A1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL3980701 | 0.61 | — | — | |
| SCHEMBL11595680 | 0.61 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL7714332 | 0.60 | — | — | |
| SCHEMBL15471190 | 0.60 | DRD4 (0.39) | ALDH1A1MAPTTSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612113-B2 | Such as N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)urea; vanilloid receptor antagonists; for treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, COPD | XENTION LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |