Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13613640 | 0.88 | TRPV1 (0.49) | TRPV1OPRM1KMT2AALDH1A1GAA | |
| SCHEMBL13613607 | 0.86 | TRPV1 (0.53) | TRPV1OPRM1MEN1KMT2AALDH1A1 | |
| SCHEMBL2733684 | 0.85 | HDAC1 (0.48) | LMNASMN1; SMN2TRPV1OPRM1MEN1 | |
| SCHEMBL2734544 | 0.85 | TRPV1 (0.48) | LMNASMN1; SMN2TRPV1OPRM1GAA | |
| SCHEMBL13613613 | 0.84 | TRPV1 (0.57) | SMN1; SMN2TRPV1OPRM1ALDH1A1 | |
| SCHEMBL13613610 | 0.84 | TRPV1 (0.53) | LMNATRPV1OPRM1KMT2AHPGD | |
| SCHEMBL13613651 | 0.84 | TRPV1 (0.53) | TRPV1OPRM1 | |
| SCHEMBL13613641 | 0.84 | TRPV1 (0.53) | TRPV1OPRM1 | |
| SCHEMBL4339142 | 0.84 | TRPV1 (0.48) | LMNASMN1; SMN2TRPV1OPRM1KMT2A | |
| SCHEMBL5111925 | 0.84 | LMNA (0.51) | LMNATRPV1KMT2AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612113-B2 | Such as N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)urea; vanilloid receptor antagonists; for treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, COPD | XENTION LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612113-B2 | Such as N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)urea; vanilloid receptor antagonists; for treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, COPD | XENTION LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |