Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.45 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733683 | 0.95 | TRPV1 (0.49) | TRPV1OPRM1NAMPTROCK1CACNA1G | |
| SCHEMBL2734543 | 0.91 | TRPV1 (0.49) | TRPV1OPRM1ROCK1ROCK2 | |
| SCHEMBL4333843 | 0.90 | TRPV1 (0.53) | TRPV1OPRM1NAMPT | |
| SCHEMBL4338606 | 0.90 | TRPV1 (0.53) | TRPV1OPRM1NAMPT | |
| SCHEMBL4333848 | 0.90 | TRPV1 (0.53) | TRPV1OPRM1NAMPT | |
| SCHEMBL2734517 | 0.90 | TRPV1 (0.48) | TRPV1OPRM1NAMPT | |
| SCHEMBL2734364 | 0.88 | TRPV1 (0.51) | TRPV1OPRM1NAMPT | |
| SCHEMBL13613633 | 0.87 | ALDH1A1 (0.50) | TRPV1OPRM1ROCK2 | |
| SCHEMBL5119080 | 0.87 | TRPV1 (0.48) | TRPV1OPRM1 | |
| SCHEMBL13613630 | 0.85 | TRPV1 (0.61) | TRPV1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612113-B2 | Such as N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)urea; vanilloid receptor antagonists; for treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, COPD | XENTION LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612113-B2 | Such as N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)urea; vanilloid receptor antagonists; for treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, COPD | XENTION LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |