Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 6/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | UGCG | Q16739 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1001568 | 0.83 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CGPARP1PARP2 | |
| SCHEMBL2023396 | 0.83 | PARP1 (0.38) | PIK3CDPIK3CAPIK3CGPARP1PARP2 | |
| SCHEMBL1001933 | 0.83 | PIK3CG (0.42) | PIK3CDPIK3CAPIK3CGPARP1PARP2 | |
| SCHEMBL2024821 | 0.83 | PARP1 (0.38) | PIK3CDPIK3CAPIK3CGPARP1PARP2 | |
| SCHEMBL8271584 | 0.83 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CGPARP1PARP2 | |
| SCHEMBL29314729 | 0.81 | PIK3CG (0.41) | PIK3CDPIK3CAPIK3CGPARP1PARP2 | |
| SCHEMBL24469663 | 0.77 | PARP1 (0.56) | PIK3CDPIK3CAPIK3CGPARP1PARP2 | |
| SCHEMBL1002130 | 0.76 | PARP1 (0.50) | PARP1PARP2HTR1AHTR2ATMEM97 | |
| SCHEMBL1002883 | 0.76 | PARP1 (0.47) | PIK3CDPIK3CAPIK3CGPARP1PARP2 | |
| SCHEMBL13613660 | 0.75 | PARP1 (0.48) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | US | disclosed |
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | GRM1, GRIN1, GRM3 | PIK3CD 1029/4885PIK3CA 1203/4885PIK3CG 1735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.