Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 7/20 | 0.51 |
| ▸ | CA2 | P00918 | 7/20 | 0.51 |
| ▸ | CA9 | Q16790 | 5/20 | 0.48 |
| ▸ | CA12 | O43570 | 4/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13613650 | 0.87 | TRPV1 (0.51) | TRPV1OPRM1 | |
| SCHEMBL13613606 | 0.86 | TRPV1 (0.59) | TRPV1OPRM1 | |
| SCHEMBL13613627 | 0.85 | TRPV1 (0.51) | TRPV1OPRM1 | |
| SCHEMBL13613612 | 0.85 | TRPV1 (0.55) | TRPV1POLBOPRM1ALDH1A1 | |
| SCHEMBL13613609 | 0.85 | TRPV1 (0.51) | TRPV1OPRM1ALDH1A1 | |
| SCHEMBL13613629 | 0.85 | TRPV1 (0.53) | TRPV1OPRM1ALDH1A1 | |
| SCHEMBL13613649 | 0.84 | TRPV1 (0.53) | TRPV1OPRM1 | |
| SCHEMBL13613645 | 0.84 | EPHX1 (0.48) | TRPV1OPRM1NAMPTALDH1A1 | |
| SCHEMBL14278363 | 0.83 | TRPV1 (0.51) | TRPV1OPRM1HTTALDH1A1 | |
| SCHEMBL4341559 | 0.82 | TRPV1 (0.59) | TRPV1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612113-B2 | Such as N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)urea; vanilloid receptor antagonists; for treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, COPD | XENTION LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612113-B2 | Such as N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)urea; vanilloid receptor antagonists; for treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, COPD | XENTION LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |