Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.65 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 4/20 | 0.47 |
| ▸ | BRAF | P15056 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2734052 | 0.94 | TRPV1 (0.61) | TRPV1EPHX2KDRBRAF | |
| SCHEMBL4332016 | 0.90 | TRPV1 (0.64) | TRPV1EPHX2 | |
| SCHEMBL2734511 | 0.89 | TRPV1 (0.60) | TRPV1KDRBRAF | |
| SCHEMBL13613590 | 0.86 | TRPV1 (0.60) | TRPV1 | |
| SCHEMBL13613700 | 0.85 | TRPV1 (0.59) | TRPV1EPHX2 | |
| SCHEMBL13613648 | 0.84 | TRPV1 (0.52) | TRPV1 | |
| SCHEMBL4333852 | 0.84 | TRPV1 (0.71) | TRPV1EPHX2KDR | |
| SCHEMBL13613692 | 0.83 | TRPV1 (0.66) | TRPV1 | |
| SCHEMBL2733683 | 0.82 | TRPV1 (0.49) | TRPV1 | |
| SCHEMBL5119080 | 0.82 | TRPV1 (0.48) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612113-B2 | Such as N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)urea; vanilloid receptor antagonists; for treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, COPD | XENTION LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612113-B2 | Such as N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl)urea; vanilloid receptor antagonists; for treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, COPD | XENTION LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |