Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434012 | 0.83 | ALDH1A1 (0.89) | ALDH1A1LDHAKMT2AHPGDMEN1 | |
| SCHEMBL2432352 | 0.78 | ALDH1A1 (0.97) | ALDH1A1LDHAKMT2AHPGDMEN1 | |
| SCHEMBL693438 | 0.70 | KMT2A (0.46) | ALDH1A1LDHAKMT2AHPGDMEN1 | |
| SCHEMBL698276 | 0.66 | MAPK1 (0.56) | ALDH1A1LDHAKMT2AHPGDMEN1 | |
| SCHEMBL2431326 | 0.65 | ALDH1A1 (0.71) | ALDH1A1LDHAKMT2AHPGDMEN1 | |
| SCHEMBL21398380 | 0.65 | MAPK1 (0.60) | ALDH1A1LDHAKMT2AHPGDMEN1 | |
| SCHEMBL24916794 | 0.64 | HTR2A (0.50) | ALDH1A1KMT2AMEN1MAPK1GAA | |
| SCHEMBL924349 | 0.64 | PDE3B (0.44) | ALDH1A1KMT2AMEN1CYP3A4MAPK1 | |
| SCHEMBL8844254 | 0.62 | KDM4E (0.40) | ALDH1A1LDHAKMT2AMEN1MAPK1 | |
| SCHEMBL9233695 | 0.62 | KDM4E (0.48) | ALDH1A1KMT2AMEN1MAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275606-A1 | Heterocyclic Compounds as MEK Inhibitors | NOVARTIS AG | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275606-A1 | Heterocyclic Compounds as MEK Inhibitors | NRAS, BRAF, MAP3K1 | ALDH1A1 1214/4885LDHA 3022/4885KMT2A 1364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.