Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11759620 | 0.88 | NAAA (0.49) | HPGDEPHX1 | |
| SCHEMBL14483835 | 0.86 | NAAA (0.51) | HPGDEPHX1 | |
| Ammonia Solution, Strong SCHEMBL11779361 | 0.86 | NAAA (0.47) | HPGDEPHX1 | |
| SCHEMBL19809501 | 0.86 | NAAA (0.51) | HPGDEPHX1 | |
| SCHEMBL14485809 | 0.85 | MAPT (0.44) | HPGDKDM4EALDH1A1EPHX1TP53 | |
| SCHEMBL10017855 | 0.81 | DHODH (0.44) | HPGDKDM4EALDH1A1MAPTDHODH | |
| SCHEMBL11510537 | 0.80 | HTT (0.44) | KDM4EALDH1A1EPHX1MAPTDHODH | |
| SCHEMBL18737357 | 0.80 | HPGD (0.43) | HPGDSMN1; SMN2PKMKDM4EALDH1A1 | |
| SCHEMBL18506505 | 0.80 | MEN1 (0.40) | HPGDSMN1; SMN2KDM4EDHODHNPSR1 | |
| Propane SCHEMBL1984331 | 0.77 | FFAR3 (0.40) | ALDH1A1DHODHNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432700-B1 | SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-04 | — | — | EP | disclosed |