Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 3/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359253 | 0.87 | LMNA (0.49) | LMNATDP1NLRP3KDM4ETRIM24 | |
| SCHEMBL6099656 | 0.82 | LMNA (0.48) | LMNATDP1NLRP3KDM4ETRIM24 | |
| SCHEMBL12824692 | 0.79 | LMNA (0.43) | LMNATDP1NLRP3KDM4ETRIM24 | |
| SCHEMBL14845715 | 0.78 | LMNA (0.45) | LMNATDP1NLRP3KDM4ETRIM24 | |
| SCHEMBL14968743 | 0.78 | LMNA (0.56) | LMNATDP1NLRP3KDM4ETRIM24 | |
| SCHEMBL12922882 | 0.75 | LMNA (0.43) | LMNATDP1NLRP3KDM4ETRIM24 | |
| Hydrochloric Acid SCHEMBL9400664 | 0.75 | POLB (0.55) | TDP1KDM4EKMT2A | |
| SCHEMBL20381145 | 0.73 | LMNA (0.43) | LMNATDP1NLRP3KDM4ETRIM24 | |
| SCHEMBL12741150 | 0.72 | LMNA (0.43) | LMNATDP1NLRP3KDM4ETRIM24 | |
| SCHEMBL1641716 | 0.71 | TDP1 (0.45) | LMNATDP1NLRP3KDM4ETRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432700-B1 | SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-04 | — | — | EP | disclosed |