Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.50 |
| ▸ | CNR1 | P21554 | 8/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3841630 | 0.92 | CRHR1 (0.43) | CRHR1CNR1CNR2MAPK1SLC6A4 | |
| SCHEMBL6670838 | 0.89 | CRHR1 (0.41) | CRHR1CNR1CNR2MAPK1SLC6A4 | |
| SCHEMBL6646501 | 0.89 | CNR1 (0.42) | CRHR1CNR1CNR2MAPK1AURKA | |
| SCHEMBL3843025 | 0.89 | CRHR1 (0.41) | CRHR1CNR1CNR2MAPK1SLC6A4 | |
| SCHEMBL3839744 | 0.89 | CNR1 (0.42) | CRHR1CNR1CNR2MAPK1SLC6A3 | |
| SCHEMBL13616936 | 0.89 | AURKA (0.41) | CRHR1CNR1CNR2MAPK1AURKA | |
| SCHEMBL3843177 | 0.86 | CRHR1 (0.41) | CRHR1CNR1CNR2MAPK1 | |
| SCHEMBL3838587 | 0.85 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL3845218 | 0.85 | MAPK1 (0.42) | CRHR1CNR1CNR2MAPK1SLC6A4 | |
| SCHEMBL3838891 | 0.81 | CRHR1 (0.47) | CRHR1CNR1CNR2MAPK1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446387-B1 | SUBSTITUTED ARYL 1,4-PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN CO LLC (US) | 2009-11-04 | — | — | EP | disclosed |