Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 18/20 | 0.58 |
| ▸ | FADS1 | O60427 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6101366 | 0.94 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL6099359 | 0.87 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL6099354 | 0.87 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL6099365 | 0.87 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL6100792 | 0.87 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL3845155 | 0.86 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL3843806 | 0.86 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL6099370 | 0.85 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL6102313 | 0.85 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL6102754 | 0.85 | CRHR1 (0.55) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446387-B1 | SUBSTITUTED ARYL 1,4-PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN CO LLC (US) | 2009-11-04 | — | — | EP | disclosed |