Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 9/20 | 0.53 |
| ▸ | LTA4H | P09960 | 6/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2736492 | 0.88 | CNR2 (0.51) | CNR2LTA4HKCNH2 | |
| SCHEMBL2736483 | 0.71 | CNR2 (0.71) | CNR2LTA4HKCNH2MAPTALDH1A1 | |
| SCHEMBL215736 | 0.70 | CNR2 (0.58) | CNR2LTA4HMAPTALDH1A1NPC1 | |
| SCHEMBL2736611 | 0.69 | CNR2 (0.43) | CNR2LTA4HKCNH2MAPT | |
| SCHEMBL13617003 | 0.68 | MMP2 (0.46) | MAPT | |
| SCHEMBL217292 | 0.67 | CNR2 (1.00) | CNR2ALDH1A1 | |
| SCHEMBL8708937 | 0.67 | CNR2 (0.49) | CNR2LTA4HKCNH2MAPTNPC1 | |
| SCHEMBL28441097 | 0.66 | NPC1 (0.54) | CNR2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL29818603 | 0.66 | NPC1 (0.54) | CNR2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL9499089 | 0.65 | NPC1 (0.52) | CNR2LTA4HKCNH2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1477186-B1 | ANTIPRURITICS | SHIONOGI & CO (JP) | 2009-11-11 | — | — | EP | disclosed |