Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 9/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.33 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | IL15 | P40933 | 1/20 | 0.31 |
| ▸ | IL2 | P60568 | 1/20 | 0.31 |
| ▸ | IL15RA | Q13261 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3843215 | 0.83 | CRHR1 (0.39) | CRHR1HSD11B1 | |
| SCHEMBL3843991 | 0.83 | CRHR1 (0.38) | CRHR1CNKSR1IL15IL2IL15RA | |
| SCHEMBL3362619 | 0.80 | CRHR1 (0.46) | CRHR1HSD11B1 | |
| SCHEMBL3839810 | 0.78 | CRHR1 (0.44) | CRHR1HSD11B1 | |
| SCHEMBL3839128 | 0.77 | CRHR1 (0.51) | CRHR1HSD11B1 | |
| SCHEMBL3843569 | 0.76 | CRHR1 (0.44) | CRHR1HSD11B1 | |
| SCHEMBL3364388 | 0.74 | CRHR1 (0.48) | CRHR1HSD11B1 | |
| SCHEMBL3843615 | 0.74 | CRHR1 (0.40) | CRHR1CNKSR1IL15IL2IL15RA | |
| SCHEMBL3844312 | 0.74 | CRHR1 (0.40) | CRHR1HSD11B1 | |
| SCHEMBL3364753 | 0.73 | CRHR1 (0.50) | CRHR1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007753-B1 | HETEROCYCLIC GABA ALPHA SUBTYPE SELECTIVE RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-11-11 | — | — | EP | disclosed |