Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | IL15 | P40933 | 1/20 | 0.32 |
| ▸ | IL15RA | Q13261 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3844049 | 0.93 | CRHR1 (0.41) | CRHR1IL15IL15RA | |
| SCHEMBL3843569 | 0.82 | CRHR1 (0.44) | CRHR1HTR2C | |
| SCHEMBL3843615 | 0.82 | CRHR1 (0.40) | CRHR1IL15IL15RAP2RX7 | |
| SCHEMBL3843991 | 0.78 | CRHR1 (0.38) | CRHR1CYP1A2CYP2C9CYP2C19IL15 | |
| SCHEMBL3842455 | 0.76 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL3839759 | 0.75 | CRHR1 (0.39) | CRHR1P2RX7 | |
| SCHEMBL3839291 | 0.73 | CRHR1 (0.37) | CRHR1HPGD | |
| SCHEMBL3843300 | 0.72 | SMN1; SMN2 (0.37) | CRHR1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL3839810 | 0.70 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL3364574 | 0.70 | CRHR1 (0.50) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007753-B1 | HETEROCYCLIC GABA ALPHA SUBTYPE SELECTIVE RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-11-11 | — | — | EP | disclosed |