Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.45 |
| ▸ | LOX | P28300 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 5/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12355378 | 0.91 | RAF1 (0.49) | KDRRAF1BRAFCSF1REPHX2 | |
| Ammonia Solution, Strong SCHEMBL1218414 | 0.85 | KDR (0.58) | KDRRAF1BRAFCSF1REPHX2 | |
| SCHEMBL1219701 | 0.85 | KDR (0.58) | KDRRAF1BRAFCSF1REPHX2 | |
| SCHEMBL12355361 | 0.83 | LOX (0.46) | LOXL2LOXKDRSCN9ASCN10A | |
| SCHEMBL2891935 | 0.81 | KDR (0.44) | KDRRAF1BRAFEPHX2 | |
| SCHEMBL5764943 | 0.81 | RAF1 (0.47) | KDRRAF1BRAFEPHX2 | |
| SCHEMBL13211296 | 0.79 | SMN1; SMN2 (0.52) | SCN9A | |
| SCHEMBL2893097 | 0.78 | RAF1 (0.48) | KDRRAF1BRAFEPHX2TEK | |
| SCHEMBL2892341 | 0.76 | RAF1 (0.42) | KDRRAF1BRAFEPHX2AURKA | |
| SCHEMBL13617889 | 0.76 | RAF1 (0.53) | KDRRAF1BRAFCSF1REPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-B1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-11-04 | — | — | EP | disclosed |