Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 9/20 | 0.53 |
| ▸ | BRAF | P15056 | 5/20 | 0.52 |
| ▸ | MET | P08581 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL619963 | 0.88 | RAF1 (0.57) | RAF1BRAFMETKDREPHX2 | |
| SCHEMBL940461 | 0.85 | KDR (0.62) | RAF1BRAFMETKDREPHX2 | |
| SCHEMBL6014106 | 0.84 | RAF1 (0.58) | RAF1BRAFMETKDREPHX2 | |
| SCHEMBL10283832 | 0.79 | RAF1 (0.49) | RAF1BRAFMET | |
| SCHEMBL28790568 | 0.79 | NR4A1 (0.53) | BRAFKDRNR4A1 | |
| SCHEMBL27576048 | 0.77 | RAF1 (0.51) | RAF1BRAFMETKDR | |
| SCHEMBL12355378 | 0.77 | RAF1 (0.49) | RAF1BRAFMETKDREPHX2 | |
| SCHEMBL12355361 | 0.76 | LOX (0.46) | RAF1BRAFMETKDREPHX2 | |
| SCHEMBL19462304 | 0.76 | PARP1 (0.44) | RAF1BRAFCSF1R | |
| SCHEMBL13618006 | 0.76 | LOXL2 (0.45) | RAF1BRAFMETKDREPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-B1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-11-04 | — | — | EP | disclosed |