Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 19/20 | 0.79 |
| ▸ | BRAF | P15056 | 17/20 | 0.79 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2894441 | 0.93 | RAF1 (0.91) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL2891794 | 0.89 | RAF1 (0.84) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL2895366 | 0.89 | RAF1 (0.98) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL2891172 | 0.88 | RAF1 (1.00) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL2891760 | 0.88 | RAF1 (1.00) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL2891145 | 0.87 | RAF1 (0.84) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL3015948 | 0.86 | RAF1 (0.71) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL1217128 | 0.83 | RAF1 (0.81) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL6451002 | 0.83 | RAF1 (0.81) | RAF1BRAFKDRLCKFYN | |
| SCHEMBL2893221 | 0.83 | RAF1 (0.71) | RAF1BRAFKDRLCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-B1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-11-04 | — | — | EP | disclosed |