Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.66 |
| ▸ | BRAF | P15056 | 16/20 | 0.63 |
| ▸ | KDR | P35968 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13211387 | 0.94 | RAF1 (0.72) | RAF1BRAFKDRNPC1RAB9A | |
| SCHEMBL2886105 | 0.88 | RAF1 (0.66) | RAF1BRAFKDRNPC1RAB9A | |
| SCHEMBL13838889 | 0.88 | RAF1 (0.66) | RAF1BRAFKDRNPC1RAB9A | |
| SCHEMBL2906212 | 0.87 | RAF1 (0.70) | RAF1BRAFKDR | |
| SCHEMBL13211399 | 0.80 | BRAF (0.68) | RAF1BRAFKDRNPC1RAB9A | |
| SCHEMBL2893834 | 0.80 | RAF1 (0.71) | RAF1BRAFKDR | |
| SCHEMBL13618151 | 0.80 | RAF1 (0.68) | RAF1BRAFKDR | |
| SCHEMBL2895305 | 0.80 | RAF1 (0.71) | RAF1BRAFKDR | |
| SCHEMBL2901751 | 0.80 | RAF1 (0.71) | RAF1BRAFKDR | |
| SCHEMBL2893047 | 0.80 | RAF1 (0.85) | RAF1BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-B1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-11-04 | — | — | EP | disclosed |