Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 9/20 | 0.54 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8265043 | 0.80 | MAOB (0.63) | MAOBMAOAACHEHTTMAPK1 | |
| SCHEMBL13618233 | 0.77 | MAOB (0.51) | MAOBMAOAHTTNPC1RAB9A | |
| SCHEMBL5987976 | 0.76 | MAOB (0.76) | MAOBMAOAACHENPC1GAA | |
| SCHEMBL8265561 | 0.76 | MAOB (0.57) | MAOBMAOAACHEHTTMAPK1 | |
| SCHEMBL30522847 | 0.74 | MAOB (0.51) | MAOBHTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18864590 | 0.74 | MAOB (0.51) | MAOBHTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12988241 | 0.74 | GRM5 (0.35) | HTTSMN1; SMN2 | |
| SCHEMBL1549250 | 0.74 | MAOB (0.68) | MAOBMAOAACHEHRH3 | |
| SCHEMBL6810689 | 0.74 | MAPT (0.39) | MAOBNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL13483792 | 0.73 | MAOB (0.61) | MAOBMAOAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |