Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL685837 | 0.79 | MAOB (0.68) | MAOBMAOAHRH3 | |
| SCHEMBL1549250 | 0.78 | MAOB (0.68) | MAOBMAOAHRH3 | |
| SCHEMBL129831 | 0.78 | TP53 (0.61) | MAOBRAB9ASMN1; SMN2GAAMAPT | |
| SCHEMBL30167753 | 0.78 | TP53 (0.61) | MAOBRAB9ASMN1; SMN2GAAMAPT | |
| SCHEMBL13618122 | 0.77 | MAOB (0.54) | MAOBNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL15344203 | 0.77 | MAOB (0.80) | MAOBMAOA | |
| SCHEMBL1547975 | 0.77 | MAOB (0.74) | MAOBMAOA | |
| Ammonia Solution, Strong SCHEMBL27820327 | 0.76 | TP53 (0.59) | MAOBNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL8265043 | 0.76 | MAOB (0.63) | MAOBHTTMAOAALDH1A1ALOX15 | |
| SCHEMBL14087633 | 0.76 | MAOB (0.58) | MAOBGAAMAPTHTTMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |