Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89147 | 0.85 | POLB (0.60) | P2RX7MAPTKDM4ENPC1POLB | |
| SCHEMBL89901 | 0.81 | MEN1 (0.56) | P2RX7MAPTKDM4EPOLBHPGD | |
| SCHEMBL3868858 | 0.78 | MAPT (0.73) | MAPTKDM4ENPC1POLBRAB9A | |
| SCHEMBL14432792 | 0.76 | KDM4E (0.51) | MAPTKDM4ENPC1POLBRAB9A | |
| SCHEMBL8265233 | 0.75 | ALDH1A1 (0.50) | MAPTKDM4EPOLBROCK2ALDH1A1 | |
| SCHEMBL18835454 | 0.75 | MEN1 (0.52) | P2RX7MAPTKDM4ENPC1POLB | |
| SCHEMBL13254952 | 0.75 | SMN1; SMN2 (0.53) | MAPTKDM4ENPC1POLBRAB9A | |
| SCHEMBL8264452 | 0.74 | TP53 (0.43) | P2RX7MAPTKDM4ENPC1POLB | |
| SCHEMBL89928 | 0.74 | HPGD (0.61) | P2RX7MAPTKDM4ECA1CA2 | |
| SCHEMBL19676843 | 0.73 | MAPT (0.49) | MAPTKDM4ENPC1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |