Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19542277 | 0.86 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2TP53HPGDKMT2A | |
| SCHEMBL18908668 | 0.82 | SMN1; SMN2 (0.59) | ALDH1A1SMN1; SMN2TP53HPGDKMT2A | |
| SCHEMBL19125639 | 0.80 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2TP53HPGDKMT2A | |
| SCHEMBL13469003 | 0.79 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HPGDKMT2ARAB9A | |
| SCHEMBL25083177 | 0.79 | TSHR (0.45) | ALDH1A1SMN1; SMN2TP53HPGDKMT2A | |
| SCHEMBL22338220 | 0.79 | TSHR (0.45) | ALDH1A1SMN1; SMN2TP53HPGDKMT2A | |
| SCHEMBL21137267 | 0.79 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2TP53HPGDKMT2A | |
| SCHEMBL20340484 | 0.78 | SMN1; SMN2 (0.66) | ALDH1A1SMN1; SMN2TP53HPGDKMT2A | |
| SCHEMBL18199495 | 0.78 | SMN1; SMN2 (0.66) | ALDH1A1SMN1; SMN2TP53HPGDKMT2A | |
| SCHEMBL10036633 | 0.78 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2TP53HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |